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Article

Procedures for reliable estimation of viral fitness from time-series data.

Proceedings. Biological sciences - 22 Sept 2002

Bonhoeffer Sebastian, Barbour Andrew D, De Boer Rob J

Abstract excerpt

In order to develop a better understanding of the evolutionary dynamics of HIV drug resistance, it is necessary to quantify accurately the in vivo fitness costs of resistance mutations. However, the reliable estimation of such fitness costs is riddled with both theoretical and experimental difficulties. Experimental fitness assays typically suffer from the shortcoming that they are based on in vitro data. Fitness...

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Identifiers

PMID: 12350250
DOI: 10.1098/rspb.2002.2097
PMCID: PMC1691111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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