Article
Genotyping methods to detect a unique neuroprotective factor (Wld(s)) for axons.
Journal of neuroscience methods - 30 Jan 2002
Mi Weiqian, Conforti Laura, Coleman Michael P
Abstract excerpt
The slow Wallerian degeneration mouse, C57BL/Wld(s), carries a dominant mutation that delays Wallerian degeneration in the distal stump of an injured axon. The protective gene has been identified and also found to protect axons from the neurotoxin vincristine. Therefore, it is important to determine whether it has a widespread application to protect axons in neurological disease. In principle, this can be done by...
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