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Article

The WldS protein protects against axonal degeneration: a model of gene therapy for peripheral neuropathy.

Annals of neurology - 1 Dec 2001

Wang M S, Fang G, Culver D G, Davis A A, Rich M M, Glass J D

Abstract excerpt

The WldS mouse is a spontaneous mutant that is characterized by the phenotype of delayed degeneration of transected nerves (slow Wallerian degeneration). Molecular genetic analysis identified a mutation in this animal that codes for a unique protein expressed in brain tissue of WldS mice. We asked whether the WldS phenotype, in addition to delaying axonal degeneration after axotomy, might provide neuroprotection...

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Identifiers

PMID: 11761475
DOI: 10.1002/ana.10039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The WldS protein protects against axonal degeneration: a model of gene therapy for peripheral neuropathy.PMID 11761475Read ↗

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Genotyping methods to detect a unique neuroprotective factor (Wld(s)) for axons.Semantic proximity Read ↗

The slow Wallerian degeneration gene <i>in vivo</i> protects motor axons but not their cell bodies after avulsion and neonatal axotomySemantic proximity Read ↗

Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.Semantic proximity Read ↗

Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues.Semantic proximity Read ↗

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.Semantic proximity Read ↗

Motor neuron death induced by axotomy in neonatal mice occurs more slowly in a mutant strain in which Wallerian degeneration is very slow.Semantic proximity Read ↗

Differential protection of neuromuscular sensory and motor axons and their endings in Wld(S) mutant mice.Semantic proximity Read ↗

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