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Article

Mutations in a P-type ATPase gene cause axonal degeneration.

PLoS genetics - 1 Jan 2012

Zhu Xianjun, Libby Richard T, de Vries Wilhelmine N, Smith Richard S, Wright Dana L, Bronson Roderick T, Seburn Kevin L, John Simon W M

Abstract excerpt

Neuronal loss and axonal degeneration are important pathological features of many neurodegenerative diseases. The molecular mechanisms underlying the majority of axonal degeneration conditions remain unknown. To better understand axonal degeneration, we studied a mouse mutant wabbler-lethal (wl). Wabbler-lethal (wl) mutant mice develop progressive ataxia with pronounced neurodegeneration in the central and...

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Identifiers

PMID: 22912588
DOI: 10.1371/journal.pgen.1002853
PMCID: PMC3415440

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