Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression

2 Mar 2006

Abstract excerpt

Hop is an unusual homeodomain protein that was first identified in the developing heart where it functions downstream of Nkx2.5 to modulate cardiac gene expression. Hop functions through interactions with histone deacetylase (HDAC) 2 to mediate repression of cardiac-specific genes, and recent studies show that HDAC activity and HDAC2 expression are decreased in people with chronic obstructive pulmonary disease....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Epigenetics and DNA Methylation
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16510470
DOI: 10.1152/ajplung.00385.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expressionPMID 16510470Read ↗

Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.Semantic proximity Read ↗

Analysis of the structure and function of the transcriptional coregulator HOP.Semantic proximity Read ↗

The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during <i>Xenopus</i> lung developmentSemantic proximity Read ↗

CHD4 is recruited by GATA4 and NKX2-5 silencers to repress non-cardiac gene programs in the developing heartSemantic proximity Read ↗

GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.Semantic proximity Read ↗

UGRP1, a Uteroglobin/Clara Cell Secretory Protein-Related Protein, Is a Novel Lung-Enriched Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription FactorSemantic proximity Read ↗

MEF2-dependent Recruitment of the HAND1 Transcription Factor Results in Synergistic Activation of Target PromotersSemantic proximity Read ↗

The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.Semantic proximity Read ↗

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.Semantic proximity Read ↗

CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in miceSemantic proximity Read ↗

Epigenetic Regulation of Surfactant Protein A Gene (<i>SP-A</i>) Expression in Fetal Lung Reveals a Critical Role for Suv39h Methyltransferases during Development and HypoxiaSemantic proximity Read ↗

WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.