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Article

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development

23 Jun 2015

Abstract excerpt

CHARGE syndrome is caused by spontaneous loss-of-function mutations to the ATP-dependant chromatin remodeller chromodomain-helicase-DNA-binding protein 7 (CHD7). It is characterised by a distinct pattern of congenital anomalies, including cardiovascular malformations. Disruption to the neural crest lineage has previously been emphasised in the aetiology of this developmental disorder. We present evidence for an...

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PMID: 26102480
DOI: 10.1016/j.ydbio.2015.06.017

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