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Article

Induction of a DNA nickase in the presence of its target site stimulates adaptive mutation in Escherichia coli.

Journal of bacteriology - 1 Oct 2002

Rodriguez Cesar, Tompkin Joshua, Hazel Jill, Foster Patricia L

Abstract excerpt

Adaptive mutation to Lac(+) in Escherichia coli strain FC40 depends on recombination functions and is enhanced by the expression of conjugal functions. To test the hypothesis that the conjugal function that is important for adaptive mutation is the production of a single-strand nick at the conjugal origin, we supplied an exogenous nicking enzyme, the gene II protein (gIIp) of bacteriophage f1, and placed its...

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Identifiers

PMID: 12270817
DOI: 10.1128/JB.184.20.5599-5608.2002
PMCID: PMC139612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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