Article
Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli.
Genetics - 1 Jan 1996
Foster P L, Trimarchi J M, Maurer R A
Abstract excerpt
Reversion of a lac- frameshift allele carried on an F' episome in Escherichia coli occurs at a high rate when the cells are placed under lactose selection. Unlike Lac+ mutations that arise during nonselective growth, the production of these adaptive mutations requires the RecA-RecBCD pathway for recombination. In this report, we show that enzymes that process recombination intermediates are involved in the...
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