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Article

Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli.

Genetics - 1 May 1999

Foster P L, Rosche W A

Abstract excerpt

Adaptive mutation has been studied extensively in FC40, a strain of Escherichia coli that cannot metabolize lactose (Lac-) because of a frameshift mutation affecting the lacZ gene on its episome. recD mutants of FC40, in which the exonuclease activity of RecBCD (ExoV) is abolished but its helicase activity is retained, have an increased rate of adaptive mutation. The results presented here show that, in several...

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Identifiers

PMID: 10224241
DOI: 10.1093/genetics/152.1.15
PMCID: PMC1460594

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Source receipt: pubmed, retrieved 7 Sept 2026.

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