Evidence that F plasmid transfer replication underlies apparent adaptive mutation.

doi:10.1126/science.7716546

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Article

Evidence that F plasmid transfer replication underlies apparent adaptive mutation.

Science (New York, N.Y.) - 21 Apr 1995

Galitski T, Roth J R

Abstract excerpt

An Escherichia coli K12 strain, FC40, has been used extensively in the analysis of adaptive mutability. This strain carries a revertible mutant lac allele on an F plasmid and accumulates Lac+ (lactose utilizing) revertants, but not unselected mutants, when placed on selective medium. These adapti...

Topics

Adaptation, Physiological
Alleles
Bacterial Proteins
Culture Media
DNA Replication
Escherichia coli
Escherichia coli Proteins
F Factor
Frameshift Mutation
Lac Operon
Lac Repressors
Lactose
Mutation
Rec A Recombinases
Repressor Proteins

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