Article
Adaptive reversion of an episomal frameshift mutation in Escherichia coli requires conjugal functions but not actual conjugation.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 1995
Foster P L, Trimarchi J M
Abstract excerpt
Adaptive reversion of a lac- frameshift mutation in Escherichia coli appears to be due to DNA polymerase errors, implying that DNA is being synthesized although the cells are not dividing. Here we report that the production of adaptive lac+ revertants (i) is much higher when the mutational target is on the F' episome than when it is on the bacterial chromosome; (ii) is enhanced by functions required for...
Topics
- Conjugation, Genetic
- Escherichia coli
- Frameshift Mutation
- Phenotype
- Plasmids