Roles of double-strand breaks, nicks, and gaps in stimulating deletions of CTG.CAG repeats by intramolecular DNA repair.

doi:10.1016/j.jmb.2005.09.023

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Article

Roles of double-strand breaks, nicks, and gaps in stimulating deletions of CTG.CAG repeats by intramolecular DNA repair.

Journal of molecular biology - 11 Nov 2005

Hebert Micheal L, Wells Robert D

Abstract excerpt

A series of plasmids harboring CTG.CAG repeats with double-strand breaks (DSB), single-strand nicks, or single-strand gaps (15 or 30 nucleotides) within the repeat regions were used to determine their capacity to induce genetic instabilities. These plasmids were introduced into Escherichia coli in the presence of a second plasmid containing a sequence that could support homologous recombination repair between the...

Topics

Base Sequence
DNA Ligases
DNA Repair
DNA-Binding Proteins
Escherichia coli
Escherichia coli Proteins
Genomic Instability
Mutation
Nucleic Acid Conformation
Plasmids
Recombination, Genetic
Sequence Deletion
Trinucleotide Repeats

Source

Open in PubMed

Identifiers

PMID: 16213518
DOI: 10.1016/j.jmb.2005.09.023

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