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Article

Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases.

The Journal of biological chemistry - 29 Nov 2002

Nangle Leslie A, De Crecy Lagard Valerie, Doring Volker, Schimmel Paul

Abstract excerpt

The rules of the genetic code are established in reactions that aminoacylate tRNAs with specific amino acids. Ambiguity in the code is prevented by editing activities whereby incorrect aminoacylations are cleared by specialized hydrolytic reactions of aminoacyl tRNA synthetases. Whereas editing reactions have long been known, their significance for cell viability is still poorly understood. Here we investigated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12244062
DOI: 10.1074/jbc.M208093200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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