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Article

BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases.

Cancer - 15 Dec 2005

Pal Tuya, Permuth-Wey Jenny, Betts Judith A, Krischer Jeffrey P, Fiorica James, Arango Hector, LaPolla James, Hoffman Mitchell, Martino Martin A, Wakeley Katie, Wilbanks George, Nicosia Santo, Cantor Alan, Sutphen Rebecca

Abstract excerpt

BACKGROUND: It is believed that BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are scant data on the prevalence and spectrum of mutations, genotype/phenotype correlations, tumor histology, and family history characteristics. To address this gap, the authors conducted a population-based study of 232 incident epithelial ovarian...

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Source

Identifiers

PMID: 16284991
DOI: 10.1002/cncr.21536

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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