Article
Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression.
The Journal of biological chemistry - 6 Aug 1999
Cho M C, Rapacciuolo A, Koch W J, Kobayashi Y, Jones L R, Rockman H A
Abstract excerpt
Calsequestrin is a high capacity Ca(2+)-binding protein in the junctional sarcoplasmic reticulum that forms a quaternary complex with junctin, triadin, and the ryanodine receptor. Transgenic mice with cardiac-targeted calsequestrin overexpression show marked suppression of Ca(2+)-induced Ca(2+) release, myocyte hypertrophy, and premature death by 16 weeks of age (Jones, L. R., Suzuki, Y. J., Wang, W., Kobayashi,...
Topics
- Age Factors
- Animals
- Calcium-Binding Proteins
- Calsequestrin
- Cardiomyopathy, Dilated
- Cyclic AMP-Dependent Protein Kinases
- Disease Models, Animal
- Down-Regulation
- Echocardiography
- Heart Function Tests