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Article

Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts.

Cellular signalling - 1 Apr 2008

Kwon Osong, Kim Kyung A, He Long, Kim Sun Ok, Kim Min Soo, Cha Eun Young, Yoon Byung Dae, Sok Dai Eun, Jung Mira, Ahn Jong Seog, Kim Bo Yeon

Abstract excerpt

DNA damage by ionizing radiation (IR) can induce activations of both NF-kappaB and p53 through the upstream kinase ataxia telangiectasia mutated (ATM). NF-kappaB activation could also be signaled through two distinct or overlapped pathways; IkappaB kinases (IKKs)-IkappaBalpha and Akt-glycogen synthase kinase-3 (GSK-3). In the present study, however, we show that activation of Akt1 and the subsequent...

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Identifiers

PMID: 18243662
DOI: 10.1016/j.cellsig.2007.10.022

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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