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Article

Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2002

Okochi Osamu, Hibi Kenji, Uemura Takanori, Inoue Soichiro, Takeda Shin, Kaneko Tetsuya, Nakao Akimasa

Abstract excerpt

PURPOSE: Somatic mutations in mitochondrial DNA (mtDNA) have recently been detected in various cancers. These mutations could possibly be detected in serum because mtDNA has a higher copy number than nuclear DNA. Thus, we examined genetic alterations in the D-loop region of mtDNA in hepatocellular carcinoma (HCC) patients. EXPERIMENTAL DESIGN: Fifty patients with HCC were investigated in this study. Somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12231530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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