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Article

Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2002

Nomoto Shuji, Yamashita Katsuya, Koshikawa Katsumi, Nakao Akimasa, Sidransky David

Abstract excerpt

PURPOSE: Hepatocellular carcinoma (HCC) is a highly malignant tumor prone to multicentric occurrence. Differentiation between a true relapse of HCC and a second primary tumor is of clinical importance. We sought to identify mitochondrial mutations in HCC and test their use as clonal markers in this disease. EXPERIMENTAL DESIGN: Primary HCC tissue samples were obtained from 19 patients and analyzed for mutations...

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PMID: 11839667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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