Article
The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease.
Neuroscience letters - 20 Sept 2002
de Silva Rohan, Hardy John, Crook Julia, Khan Naheed, Graham Elizabeth A, Morris Christopher M, Wood Nicholas W, Lees Andrew J
Abstract excerpt
Mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. Three studies have also shown an association of the tau locus with clinically diagnosed Parkinson's disease. Noting the significant incidence of clinical misdiagnosis...
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