Article
The effect of tau genotype on clinical features in FTDP-17.
Parkinsonism & related disorders - 1 Jun 2005
Baba Yasuhiko, Tsuboi Yoshio, Baker Matthew C, Uitti Ryan J, Hutton Michael L, Dickson Dennis W, Farrer Matthew, Putzke John D, Woodruff Bryan K, Ghetti Bernardino, Murrell Jill R, Boeve Bradley F, Petersen Ronald C, Verpillat Patrice, Brice Alexis, Delisle Marie-Bernadette, Rascol Oliver, Arima Kunimasa, Dysken Maurice W, Yasuda Minoru, Kobayashi Tomonori, Sunohara Nobuhiko, Komure Osamu, Kuno Sadako, Sperfeld Anne D, Stoppe Gabriela, Kohlhase Jürgen, Pickering-Brown Stuart, Neary David, Bugiani Orso, Wszolek Zbigniew K
Abstract excerpt
The clinical phenotype of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) varies. This variability is seen not only between kindreds with different mutations but also in families sharing the same mutation. Inheritance of tau haplotype (H1) and genotype (H1/H1) has been established as a risk factor for some neurodegenerative disorders with parkinsonism. We assessed the effect of tau...
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