Article
Genetics of Parkinson's disease and biochemical studies of implicated gene products.
Current opinion in cell biology - 1 Oct 2002
Lansbury Peter T, Brice Alexis
Abstract excerpt
Parkinson's disease was thought, until recently, to have little or no genetic component. This notion has changed with the identification of three genes, and the mapping of five others, that are linked to rare familial forms of the disease (FPD). The products of the identified genes, alpha-synuclein (PARK 1), parkin (PARK 2), and ubiquitin-C-hydrolase-L1 (PARK 5) are the subject of intense cell-biological and...
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