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Recent advances in the genetics and pathogenesis of Parkinson disease

22 Jan 2002

Abstract excerpt

The identification of three genes and several additional loci associated with inherited forms of levodopa-responsive PD has confirmed that this is not a single disorder. Yet, analyses of the structure and function of these gene products point to the critical role of protein aggregation in dopaminergic neurons of the substantia nigra as the common mechanism leading to neurodegeneration in all known forms of this...

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PMID: 11805242
DOI: 10.1212/wnl.58.2.179

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