Article
Genetics of Parkinson's disease.
Annals of the New York Academy of Sciences - 1 Jan 2000
Polymeropoulos M H
Abstract excerpt
Several genetic factors have been recently recognized as related to the etiology of Parkinson's disease. Mutations in the genes coding for alpha-synuclein and ubiquitin carboxy-terminal hydrolase have been identified in families with autosomal dominant Parkinson's disease. Mutations in the Parkin gene are responsible for autosomal recessive parkinsonism. These first pieces of the molecular puzzle of Parkinson's...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Genes, Dominant
- Genes, Recessive
- Humans
- Ligases
- Mutation
- Nerve Tissue Proteins
- Parkinson Disease
- Proteins
- Synucleins
- Thiolester Hydrolases