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Article

Cytochrome P450 1B1 Determines Susceptibility to Dibenzo[a,l]pyrene-Induced Tumor Formation

8 Aug 2002

Abstract excerpt

Metabolic activation, DNA binding, and tumorigenicity of the carcinogenic polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) catalyzed by murine cytochrome P450 (P450) enzymes were investigated. DNA binding of DB[a,l]P in human mammary carcinoma MCF-7 and human P450-expressing Chinese hamster V79 cell lines was previously shown to occur preferentially with metabolically generated fjord region...

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Identifiers

PMID: 12230405
DOI: 10.1021/tx020017q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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