Article
Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis.
Genes, chromosomes & cancer - 1 Mar 2004
Mollenhauer Jan, Helmke Burkhard, Medina Daniel, Bergmann Gaby, Gassler Nikolaus, Müller Hanna, Lyer Stefan, Diedrichs Laura, Renner Marcus, Wittig Rainer, Blaich Stephanie, Hamann Ute, Madsen Jens, Holmskov Uffe, Bikker Floris, Ligtenberg Antoon, Carlén Anette, Olsson Jan, Otto Herwart F, O'Malley Bert, Poustka Annemarie
Abstract excerpt
Deleted in malignant brain tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor for brain and epithelial cancer. Initial studies suggested loss of expression rather than mutation as the predominant mode of DMBT1 inactivation. However, in situ studies in lung cancer demonstrated highly sophisticated changes of DMBT1 expression and localization, pointing to a chronological order of events. Here we...
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