High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

doi:10.1038/ncomms5699

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Article

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Nature communications - 21 Aug 2014

Grimm Christian, Holdt Lesca M, Chen Cheng-Chang, Hassan Sami, Müller Christoph, Jörs Simone, Cuny Hartmut, Kissing Sandra, Schröder Bernd, Butz Elisabeth, Northoff Bernd, Castonguay Jan, Luber Christian A, Moser Markus, Spahn Saskia, Lüllmann-Rauch Renate, Fendel Christina, Klugbauer Norbert, Griesbeck Oliver, Haas Albert, Mann Matthias, Bracher Franz, Teupser Daniel, Saftig Paul, Biel Martin, Wahl-Schott Christian

Abstract excerpt

Endolysosomal organelles play a key role in trafficking, breakdown and receptor-mediated recycling of different macromolecules such as low-density lipoprotein (LDL)-cholesterol, epithelial growth factor (EGF) or transferrin. Here we examine the role of two-pore channel (TPC) 2, an endolysosomal cation channel, in these processes. Embryonic mouse fibroblasts and hepatocytes lacking TPC2 display a profound...

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PMID: 25144390
DOI: 10.1038/ncomms5699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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