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LAMP-2: A control step for phagosome and autophagosome maturation

16 May 2008

Abstract excerpt

The two structurally related, major lysosomal membrane proteins LAMP-1 and LAMP-2 were for a long time regarded as crucial for the protection of the lysosomal membrane from the hostile lumenal environment. However, recent studies on the effects of single and combined LAMP-deficiency in mice reveal alternative functions. LAMP proteins, but especially LAMP-2, are important regulators in successful maturation of...

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PMID: 18376150
DOI: 10.4161/auto.5724

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