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Article

LRRK2 deficiency impairs trans-Golgi to lysosome trafficking and endocytic cargo degradation in human renal proximal tubule epithelial cells.

American journal of physiology. Renal physiology - 1 Nov 2018

Lanning Nathan J, VanOpstall Calvin, Goodall Megan L, MacKeigan Jeffrey P, Looyenga Brendan D

Abstract excerpt

Defects in vesicular trafficking underlie a wide variety of human diseases. Genetic disruption of leucine-rich repeat kinase 2 (LRRK2) in rodents results in epithelial vesicular trafficking errors that can also be induced by treatment of animals with LRRK2 kinase inhibitors. Here we demonstrate that defects in human renal cells lacking LRRK2 phenocopy those seen in the kidneys of Lrrk2 knockout mice,...

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Identifiers

PMID: 30089035
DOI: 10.1152/ajprenal.00009.2018
PMCID: PMC6293309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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