Article
Interleukin 1 alpha gene polymorphism as a susceptibility factor in Alzheimer's disease and its influence on the extent of histopathological hallmark lesions of Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2002
Pirskanen Mia, Hiltunen Mikko, Mannermaa Arto, Iivonen Susan, Helisalmi Seppo, Lehtovirta Maarit, Koivisto Anne Maria, Laakso Markku, Soininen Hilkka, Alafuzoff Irina
Abstract excerpt
We investigated the association of the interleukin 1alpha (IL1A) (-889) C/T polymorphism with Alzheimer's disease (AD) and with the extent of AD histopathological lesions, the senile/neuritic plaques (SPs/NPs) and neurofibrillary tangles. We evaluated 98 neuropathologically confirmed AD patients and 240 controls as well as 146 clinically diagnosed AD patients and 278 controls but found no association of the IL1A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.