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Article

Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.

The Journal of biological chemistry - 8 Nov 2002

Gu Jian-Ming, Crawley James T B, Ferrell Gary, Zhang Fangjiu, Li Weihong, Esmon Naomi L, Esmon Charles T

Abstract excerpt

The endothelial cell protein C receptor (EPCR) is a type 1 transmembrane protein found primarily on endothelium that binds both protein C and activated protein C with similar affinity. EPCR augments the activation of protein C by the thrombin-thrombomodulin complex. To determine the physiological importance of EPCR, we generated EPCR-deficient mice by homologous targeting in embryonic stem cells. Genotyping of...

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Identifiers

PMID: 12218060
DOI: 10.1074/jbc.M207538200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.PMID 12218060Read ↗

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