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Article

A role for thrombin receptor signaling in endothelial cells during embryonic development.

Science (New York, N.Y.) - 31 Aug 2001

Griffin C T, Srinivasan Y, Zheng Y W, Huang W, Coughlin S R

Abstract excerpt

The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a role for PAR1, a protease-activated G protein-coupled receptor for thrombin, in embryonic development. Approximately half of Par1-/- mouse embryos died at midgestation with bleeding from multiple sites. PAR1 is expressed in endothelial cells, and a PAR1 transgene...

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Identifiers

PMID: 11533492
DOI: 10.1126/science.1061259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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