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Article

Extraembryonic expression of EPCR is essential for embryonic viability.

Blood - 15 Oct 2005

Li Weihong, Zheng Xunzhen, Gu Jian-Ming, Ferrell Gary L, Brady Mingming, Esmon Naomi L, Esmon Charles T

Abstract excerpt

The endothelial cell protein C receptor (EPCR) augments protein C activation by the thrombin-thrombomodulin complex. Deletion of the EPCR gene (Procr) in mice leads to embryonic lethality before embryonic day 10 (E10.0). EPCR is detected in the giant trophoblast cells at the feto-maternal boundary from E7.5 and weakly in embryonic aortic endothelial cells from E13.5, suggesting that extraembryonic EPCR expression...

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Identifiers

PMID: 15956290
DOI: 10.1182/blood-2005-01-0406
PMCID: PMC1895308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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