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Article

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995

Healy A M, Rayburn H B, Rosenberg R D, Weiler H

Abstract excerpt

We have targeted the murine thrombomodulin (TM) gene in embryonic stem cells and generated embryos as well as mice with TM deficiency. The heterozygous TM-deficient (TM+/-) mice as compared to wild-type (TM+/+) littermates exhibit 50% reductions in the levels of TM mRNA and TM protein. However, TM+/- mice appear normal and are free of thrombotic complications. The homozygous TM-deficient (TM-/-) embryos die...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7846065
DOI: 10.1073/pnas.92.3.850
PMCID: PMC42718

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Source receipt: pubmed, retrieved 7 Sept 2026.

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