Article
Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995
Healy A M, Rayburn H B, Rosenberg R D, Weiler H
Abstract excerpt
We have targeted the murine thrombomodulin (TM) gene in embryonic stem cells and generated embryos as well as mice with TM deficiency. The heterozygous TM-deficient (TM+/-) mice as compared to wild-type (TM+/+) littermates exhibit 50% reductions in the levels of TM mRNA and TM protein. However, T...
Topics
- Animals
- Base Sequence
- Cardiovascular System
- Chimera
- Crosses, Genetic
- Embryonic and Fetal Development
- Female
- Gene Targeting
- Genes, Lethal
- Male
- Mice
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Stem Cells
- Thrombomodulin