Article
Pulmonary carcinogenesis in transgenic mice.
Experimental lung research - 1 Jan 2000
Maronpot R R, Palmiter R D, Brinster R L, Sandgren E P
Abstract excerpt
Use of genetically engineered mice offers a unique approach to identifying and investigating factors that may influence tumor development. We have used conventional histopathologic and ultrastructural techniques to characterize lung tumors in three lines of transgenic mice bearing an albumin enhancer/promoter linked to a mutated human H-ras gene. Mice in all three lines developed multiple alveolar-bronchiolar...
Topics
- Albumins
- Animals
- Enhancer Elements, Genetic
- Female
- Genes, ras
- Lung Neoplasms
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Mutation
- Promoter Regions, Genetic