Differential susceptibility of transgenic mice expressing human surfactant protein B genetic variants to Pseudomonas aeruginosa induced pneumonia.

doi:10.1016/j.bbrc.2015.11.089

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Article

Differential susceptibility of transgenic mice expressing human surfactant protein B genetic variants to Pseudomonas aeruginosa induced pneumonia.

Biochemical and biophysical research communications - 8 Jan 2016

Ge Lin, Liu Xinyu, Chen Rimei, Xu Yongan, Zuo Yi Y, Cooney Robert N, Wang Guirong

Abstract excerpt

Surfactant protein B (SP-B) is essential for lung function. Previous studies have indicated that a SP-B 1580C/T polymorphism (SNP rs1130866) was associated with lung diseases including pneumonia. The SNP causes an altered N-linked glycosylation modification at Asn129 of proSP-B, e.g. the C allele with this glycosylation site but not in the T allele. This study aimed to generate humanized SP-B transgenic mice...

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Identifiers

PMID: 26620227
DOI: 10.1016/j.bbrc.2015.11.089
PMCID: PMC4698049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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