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Article

Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1.

Brain research - 13 Sept 2002

Takeuchi Hideyuki, Kobayashi Yasushi, Yoshihara Tsuyoshi, Niwa Jun-ichi, Doyu Manabu, Ohtsuka Kenzo, Sobue Gen

Abstract excerpt

Mutations of the superoxide dismutase 1 (SOD1) gene cause familial amyotrophic lateral sclerosis (FALS). Intracytoplasmic aggregate formation consisting of mutant SOD1 is the histological hallmark of FALS. Since a previous report revealed that Hsp70 reduced aggregate formation and cell death in a cell model of FALS, here we examined the combined effects of Hsp70 and its cofactor, Hsp40, on a cell model of FALS....

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Source

Identifiers

PMID: 12213295
DOI: 10.1016/s0006-8993(02)02568-4

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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