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Article

Amyotrophic lateral sclerosis: a proposed mechanism.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 2002

Okado-Matsumoto Ayako, Fridovich Irwin

Abstract excerpt

Missense mutations in Cu,Zn-superoxide dismutase (SOD1) account for approximately 20% of familial amyotrophic lateral sclerosis (FALS) through some, as yet undefined, toxic gain of function that leads to gradual death of motor neurons. Mitochondrial swelling and vacuolization are early signs of incipient motor neuron death in FALS. We previously reported that SOD1 exists in the intermembrane space of...

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Identifiers

PMID: 12060716
DOI: 10.1073/pnas.132260399
PMCID: PMC124414

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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