Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upregulation of HSP27 in a transgenic model of ALS.

Journal of neuropathology and experimental neurology - 1 Nov 2002

Vleminckx Vicky, Van Damme Philip, Goffin Karolien, Delye Hans, Van Den Bosch Ludo, Robberecht Wim

Abstract excerpt

Mutations of the SOD1 gene underlie 1 form of familial amyotrophic lateral sclerosis (ALS). Their pathogenic mechanism remains uncertain, but is thought to involve oxidative stress and abnormal protein aggregation, 2 processes known to induce heat shock proteins (HSPs). We studied the expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Crystallin B Chain
Share to Heat-Shock Proteins
Share to HSP70 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Chaperones

Share to Neuroglia

Share to Spinal Cord

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 12430713
DOI: 10.1093/jnen/61.11.968

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12430713-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upregulation of HSP27 in a transgenic model of ALS.PMID 12430713Read ↗

Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells.Semantic proximity Read ↗

Transgenic mouse models of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Over-expression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouseSemantic proximity Read ↗

Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein inductionSemantic proximity Read ↗

Overexpression of mutant HSP27 causes axonal neuropathy in mice.Semantic proximity Read ↗

The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of β‐amyloid peptideSemantic proximity Read ↗

HSP27 and cell survival in neurones.Semantic proximity Read ↗

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.Semantic proximity Read ↗

Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.Semantic proximity Read ↗

Exogenous Delivery of Heat Shock Protein 70 Increases Lifespan in a Mouse Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.