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Article

Upregulation of HSP27 in a transgenic model of ALS.

Journal of neuropathology and experimental neurology - 1 Nov 2002

Vleminckx Vicky, Van Damme Philip, Goffin Karolien, Delye Hans, Van Den Bosch Ludo, Robberecht Wim

Abstract excerpt

Mutations of the SOD1 gene underlie 1 form of familial amyotrophic lateral sclerosis (ALS). Their pathogenic mechanism remains uncertain, but is thought to involve oxidative stress and abnormal protein aggregation, 2 processes known to induce heat shock proteins (HSPs). We studied the expression of 3 HSPs (alphaB-crystallin, HSP27, and HSP70) in transgenic mice overexpressing human mutant (G93A and G37R) SOD1,...

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Identifiers

PMID: 12430713
DOI: 10.1093/jnen/61.11.968

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Upregulation of HSP27 in a transgenic model of ALS.PMID 12430713Read ↗

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Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouseSemantic proximity Read ↗

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