Article
Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2000
Carmichael J, Chatellier J, Woolfson A, Milstein C, Fersht A R, Rubinsztein D C
Abstract excerpt
Huntington's disease (HD) is an autosomal dominant neurodegenerative condition caused by expansions of more than 35 uninterrupted CAG repeats in exon 1 of the huntingtin gene. The CAG repeats in HD and the other seven known diseases caused by CAG codon expansions are translated into long polyglutamine tracts that confer a deleterious gain of function on the mutant proteins. Intraneuronal inclusions comprising...
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