Article

Reversal learning paradigm reveals deficits in cognitive flexibility in the Fmr1 knockout male mouse

2018-06-07

Abstract excerpt

<h4>Background: </h4> Loss of FMR1 is associated with Fragile X syndrome, amongst the most prevalent inherited intellectual disability. Despite extensive research in this area, previous studies have failed to detect consistent evidence of cognitive impairments in the Morris water maze (MWM) task in the Fmr1 knockout (KO) mouse. However, few studies have examined cognitive flexibility in a reversal form of the MW...

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Literature Corpus work: 402dee88-c4b9-51d0-b0bf-66b55418428a
DOI: 10.12688/f1000research.14969.1

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