Article
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1997
Lu Y M, Jia Z, Janus C, Henderson J T, Gerlai R, Wojtowicz J M, Roder J C
Abstract excerpt
Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other glutamate receptors. The CNS revealed normal...
Topics
- Animals
- Behavior, Animal
- Binding, Competitive
- Central Nervous System
- Conditioning, Psychological
- Cycloleucine
- Fear
- Hippocampus
- Learning Disabilities
- Long-Term Potentiation
- Maze Learning
- Mice
- Mice, Inbred Strains
- Mutation
- Receptors, Metabotropic Glutamate