Molecular genetic dissection of mouse unconventional myosin-VA: head region mutations.

doi:10.1093/genetics/148.4.1951

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Article

Molecular genetic dissection of mouse unconventional myosin-VA: head region mutations.

Genetics - 1 Apr 1998

Huang J D, Cope M J, Mermall V, Strobel M C, Kendrick-Jones J, Russell L B, Mooseker M S, Copeland N G, Jenkins N A

Abstract excerpt

The mouse dilute (d) locus encodes unconventional myosin-VA (MyoVA). Mice carrying null alleles of dilute have a lightened coat color and die from a neurological disorder resembling ataxia and opisthotonus within three weeks of birth. Immunological and ultrastructural studies suggest that MyoVA i...

Topics

Alleles
Animals
Crystallography, X-Ray
Female
Gene Expression
Hair Color
Intermediate Filament Proteins
Male
Mice
Models, Molecular
Mutagenesis
Myosin Heavy Chains
Myosin Type V

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