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Article

Molecular genetic dissection of mouse unconventional myosin-VA: head region mutations.

Genetics - 1 Apr 1998

Huang J D, Cope M J, Mermall V, Strobel M C, Kendrick-Jones J, Russell L B, Mooseker M S, Copeland N G, Jenkins N A

Abstract excerpt

The mouse dilute (d) locus encodes unconventional myosin-VA (MyoVA). Mice carrying null alleles of dilute have a lightened coat color and die from a neurological disorder resembling ataxia and opisthotonus within three weeks of birth. Immunological and ultrastructural studies suggest that MyoVA is involved in the transport of melanosomes in melanocytes and smooth endoplasmic reticulum in cerebellar Purkinje...

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Identifiers

PMID: 9560408
DOI: 10.1093/genetics/148.4.1951
PMCID: PMC1460099

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Molecular genetic dissection of mouse unconventional myosin-VA: head region mutations.PMID 9560408Read ↗

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