Article
Structural basis of cargo recognitions for class V myosins.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2013
Wei Zhiyi, Liu Xiaotian, Yu Cong, Zhang Mingjie
Abstract excerpt
Class V myosins (MyoV), the most studied unconventional myosins, recognize numerous cargos mainly via the motor's globular tail domain (GTD). Little is known regarding how MyoV-GTD recognizes such a diverse array of cargos specifically. Here, we solved the crystal structures of MyoVa-GTD in its apo-form and in complex with two distinct cargos, melanophilin and Rab interacting lysosomal protein-like 2. The...
Topics
- Amino Acid Sequence
- Binding Sites
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Myosins
- Protein Conformation
- Sequence Homology, Amino Acid