Article
Fine mapping of the IBD1 locus did not identify Crohn disease-associated NOD2 variants: implications for complex disease genetics.
American journal of medical genetics - 15 Aug 2002
van Heel David A, McGovern Dermot P B, Cardon Lon R, Dechairo Bryan M, Lench Nicholas J, Carey Alisoun H, Jewell Derek P
Abstract excerpt
Crohn disease (CD) is a chronic relapsing inflammatory condition of the gastrointestinal tract. Recently, polymorphisms in NOD2 (CARD15), a gene mapping to the chromosome 16 IBD1 susceptibility locus, have been associated with susceptibility to CD. One group identified the gene by using classic positional cloning methods. Here, we report linkage and fine mapping analyses using 27 microsatellite markers...
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