Article
Association of NOD2 with Crohn's disease in a homogenous Irish population.
European journal of human genetics : EJHG - 1 Mar 2003
Bairead Emer, Harmon Dawn L, Curtis Anne M, Kelly Yvette, O'Leary Clare, Gardner Michelle, Leahy Dermot T, Vaughan Pat, Keegan Denise, O'Morain Colm, O'Donoghue Diarmuid, Shanahan Fergus, Parfrey Nollaig A, Quane Kathleen A
Abstract excerpt
Linkage of IBD to the pericentromeric region of chromosome 16 has been widely confirmed by analyses of multiple populations. The NOD2 gene is located in the peak region of linkage on chromosome 16 and thought to be involved in the activation of nuclear factor (NF) kappaB in response to bacterial components. Mutations in the NOD2 gene are found to be strongly associated with susceptibility to Crohn's disease (CD)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.