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Article

Dissecting the genetics of complex inheritance: linkage disequilibrium mapping provides insight into Crohn disease.

American journal of human genetics - 9 Dec 2011

Elding Heather, Lau Winston, Swallow Dallas M, Maniatis Nikolas

Abstract excerpt

Family studies for Crohn disease (CD) report extensive linkage on chromosome 16q and pinpoint NOD2 as a possible causative locus. However, linkage is also observed in families that do not bear the most frequent NOD2 causative mutations, but no other signals on 16q have been found so far in published genome-wide association studies. Our aim is to identify this missing genetic contribution. We apply a powerful...

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Topics

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Share to Antigens, CD
Share to Cadherins
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Deubiquitinating Enzyme CYLD

Share to Heredity

Share to Interferon Regulatory Factors

Share to Nod2 Signaling Adaptor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22152681
DOI: 10.1016/j.ajhg.2011.11.006
PMCID: PMC3234369

Genes

NOD2
CDH1
CDH3
CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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