Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Excess beta-catenin promotes accumulation of transcriptionally active p53.

The EMBO journal - 1 Jun 1999

Damalas A, Ben-Ze'ev A, Simcha I, Shtutman M, Leal J F, Zhurinsky J, Geiger B, Oren M

Abstract excerpt

beta-catenin is a multifunctional protein, acting both as a structural component of the cell adhesion machinery and as a transducer of extracellular signals. Deregulated beta-catenin protein expression, due to mutations in the beta-catenin gene itself or in its upstream regulator, the adenomatous polyposis coli (APC) gene, is prevalent in colorectal cancer and in several other tumor types, and attests to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cysteine Proteinase Inhibitors
Share to Desmoplakins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dishevelled Proteins

Share to Leupeptins

Share to Phosphoproteins

Share to Proto-Oncogene Proteins c-mdm2

Share to Solubility

Source

Open in PubMed Open full text

Identifiers

PMID: 10357817
DOI: 10.1093/emboj/18.11.3054
PMCID: PMC1171387

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Excess beta-catenin promotes accumulation of transcriptionally active p53.PMID 10357817Read ↗

Down-regulation of beta-catenin by activated p53.Semantic proximity Read ↗

P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells.Semantic proximity Read ↗

Regulation of p53Semantic proximity Read ↗

Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.Semantic proximity Read ↗

P53 and beta-catenin in colorectal cancer progression.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Beta-catenin cleavage enhances transcriptional activation.Semantic proximity Read ↗

Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancerSemantic proximity Read ↗

[Roles of beta-catenin overexpression and adenomatous polyposis coli mutation in head and neck cancer].Semantic proximity Read ↗

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.Semantic proximity Read ↗

Frequent alterations of the beta-catenin protein in cancer of the uterine cervix.Semantic proximity Read ↗

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.