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Article

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

Cancer research - 15 Mar 1998

Sparks A B, Morin P J, Vogelstein B, Kinzler K W

Abstract excerpt

Mutation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates the majority of colorectal (CR) cancers. One consequence of this inactivation is constitutive activation of beta-catenin/Tcf-mediated transcription. To further explore the role of the APC/beta-catenin/Tcf pathway in CR tumorigenesis, we searched for mutations in genes implicated in this pathway in CR tumors lacking APC mutations. No...

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Source

Identifiers

PMID: 9515795

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.PMID 9515795Read ↗

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Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.Semantic proximity Read ↗

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