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Article

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

Cancer research - 15 Mar 1998

Sparks A B, Morin P J, Vogelstein B, Kinzler K W

Abstract excerpt

Mutation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates the majority of colorectal (CR) cancers. One consequence of this inactivation is constitutive activation of beta-catenin/Tcf-mediated transcription. To further explore the role of the APC/beta-catenin/Tcf pathway in...

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Source

Identifiers

PMID: 9515795

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9515795-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.PMID 9515795Read ↗

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Expression and mutation pattern of β-catenin and adenomatous polyposis coli in colorectal cancer patients.Semantic proximity Read ↗

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Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation.Semantic proximity Read ↗

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