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Article

Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: no major role for class II or class III regions of HLA.

Genes and immunity - 1 Sept 2002

Peacock C S, Sanjeevi C B, Shaw M-A, Collins A, Campbell R D, March R, Silveira F, Costa J, Coste C H, Nascimento M D, Siddiqui R, Shaw J J, Blackwell J M

Abstract excerpt

Familial aggregation, high relative risk to siblings, and segregation analysis, suggest genetic control of visceral leishmaniasis in Brazil. Class II gene effects in mice, and high circulating tumour necrosis factor alpha in humans, provide reasons to target HLA. Fifteen polymorphic markers across 1.03 Mb (DQB1 to TNFa) were genotyped (87 multicase families; 638 individuals). Model-based parametric analyses using...

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Source

Identifiers

PMID: 12209362
DOI: 10.1038/sj.gene.6363852

Genes

NPL
LTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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