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Article

Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes.

Genes and immunity - 1 Jun 2001

Shaw M A, Donaldson I J, Collins A, Peacock C S, Lins-Lainson Z, Shaw J J, Ramos F, Silveira F, Blackwell J M

Abstract excerpt

Previous analyses indicate major gene control of susceptibility to leprosy per se and the HLA class II region has been implicated in determining susceptibility and control of clinical phenotype. Segregation analysis using data from 76 Brazilian leprosy multi-case pedigrees (1166 individuals) supported a two locus model as the best fit: a recessive major gene and a recessive modifier gene(s) (single locus vs two...

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Source

Identifiers

PMID: 11477474
DOI: 10.1038/sj.gene.6363754

Genes

TNF
LTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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